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TriMix is administered as a penile self-injection, typically considered to be the most powerful class of anti-erectile dysfunction agents. TriMix contains three drugs from complimentary classes designed to act synergistically, mixed into a sterile injection. They are:. A drug that causes blood vessels to expand vasodilator ; it produces an erection by allowing for increased blood flow to the penis. Papaverine interacts with adenylate cyclase resulting in increased cyclic adenosine monophosphate cAMP production, ultimately resulting in increased erectile capacity by relaxation of penile smooth muscle.
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TriMix injections consist of a formulation of three drugs that are compounded to treat erectile dysfunction. These three drugs are phentolamine, papaverine and alprostadil. Each drug plays - Read More. Each drug plays a different role where they complement each other and create a synergy effect.
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Although the thought of penile injections usually instigates a negative response in most men they are one of the most effective treatment methods available. Advantages include only administering tiny doses at the site of action which results in fewer side effects, and in many instances it is more effective than any other form of treatment. QuadMix includes the addition of atropine which may work synergistically to cause smooth muscle relaxation in the penis. In a study conducted by Israilov and colleagues, 13 patients that failed Trimix had a positive response to Quadmix.
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